| Literatur, Patente |
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O'Shaugnessy: "Monograph on Cannabis Medicine" 1839 Abhandlung
zur medizinischen Verwendung von Cannabis.. |
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"New Billion-Dollar Crop" Popular Mechanics 2.1938 die erste
vollautomatische Hanf-Schälmaschine.. |
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"Cancer Curb Is Studied" Washington Post 18.8.1974 Studie
am Medical College Virginia NIH-gefördert.. THC verlangsamt Krebswachstum
bei Mäusen.. Lungenkrebs, Brustkrebs, Virusausgelöste Leukämie..
bis 36% Lebensverlängerung.. |
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Munson, Harris, Friedman, Dewey, Carchman: "Antineoplastic activity
of cannabinoids" J Natl Cancer Inst 55,3 597-602 9.1975 orales
THC hemmt Lewis-Lungenadenokarzinom.. dosisabhängiger Effekt nach
10 Tagen Behandlung.. kleinerer Primärtumor durch 20 Tage Behandlung..
mittlere Lebenszeit +36% bei 100mg/kg.. kein Effekt bei L1210 murine
leukemia.. hemmt Friend Leukämievirus um 71%.. |
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Carchman, Harris, Munson: "The inhibition of DNA synthesis by
cannabinoids" Cancer Res 36,1 95-100 1.1976 |
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Friedman: "In vivo effects of cannabinoids on macromolecular
biosynthesis in Lewis lung carcinomas" J Natl Cancer Inst 56,3
655-658 3.1976 |
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Friedman: "In vivo effects of cannabinoids on macromolecular
biosynthesis in Lewis lung carcinomas" Cancer Biochem Biophys 2,2
51-54 1977 |
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Ottersen, Rosenqvist, Turner, El-Feraly: "The crystal and molecular
structure of cannabidiol" Acta Chem Scand B31,9 807-812 1977 |
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Tucker, Friedman: "Effects of cannabinoids on L1210 murine leukemia.
1. Inhibition of DNA synthesis" Cancer Biochem Biophys 2,2 51-54
1977 |
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Cunha, Carlini, Pereira, Ramos, Pimentel, Gagliardi, Sanvito, Lander,
Mechoulam: "Chronic administration of cannabidiol to healthy volunteers
and epileptic patients" Pharmacology 21,3 175-185 1980 |
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Consroe, Kudraya, Schmitz: "Acute and chronic antiepileptic drug
effects in audiogenic seizure-susceptible rats" Exp Neurology 70,3
626-637 12.1980 |
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Carlini, Cunha: "Hypnotic and antiepileptic effects of cannabidiol"
J Clin Pharmacol 21 417S-427S 1981 |
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Karler, Turkanis: "The cannabinoids as potential antiepileptics"
J Clin Pharmacol 21,8-9 Suppl 437S-448S 1981 |
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Consroe, Martin, Singh: "Antiepileptic potential of cannabidiol
analogs" J Clin Pharmacol 21,8-9 Suppl 428S-436S 1981 |
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Murison, Chubb, Maeda, Gemmell, Huberman: "Cannabinoids induce
incomplete maturation of cultured human leukemia cells" Proc Natl
Acad Sci 84:5414-5418 1987 |
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Baek, Kim, Kwag, Choi, Jung, Han: "Boron trifluoride etherate
on silica-A modified Lewis acid reagent (VII). Antitumor activity of
cannabigerol against human oral epitheloid carcinoma cells" Arch
Pharm Res 21,3 353-356 6.1998 |
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Melck, De Petrocellis, Orlando, Bisogno, Laezza, Bifulco, Di Marzo:
"Suppression of nerve growth factor Trk receptors and prolactin
receptors by endocannabinoids leads to inhibition of human breast and
prostate cancer cell proliferation" Eur J Biochem 254,3 634-642
15.6.1998 |
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Jacobsson, Wallin, Fowler: "Inhibition of rat C6 glioma cell
proliferation by endogenous and synthetic cannabinoids. Relative involvement
of cannabinoid and vanilloid receptors" Proc Natl Acad Sci USA
95,14 8375-8380 7.7.1998 |
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De Petrocellis, Melck, Palmisano, Bisogno, Laezza, Bifulco, Di Marzo:
"The endogenous cannabinoid anandamide inhibits human breast cancer
cell proliferation" Proc Natl Acad Sci USA 95,14 8375-8380 7.7.1998 |
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Sánchez, Galve-Roperh, Canova, Brachet, Guzman: "Delta9-tetrahydrocannabinol
induces apoptosis in C6 glioma cells" FEBS Lett 436,1 6-10 25.9.1998
Cannabis gg. Gliomzellen.. |
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Ruiz, Miguel, Díaz-Laviada: "Delta9-tetrahydrocannabinol
induces apoptosis in human prostate PC-3 cells via a receptor-independent
mechanism" FEBS Lett 458,3 400-404 24.9.1999 |
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De Petrocellis, Melck, Bisogno, Di Marzo: "Endocannabinoids and
fatty acid amides in cancer, inflammation and related disorders"
Endocrinology 141,1 118-126 1.2000 |
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Galve-Roperh, Sánchez, Cortés, Gómez del Pulgar,
Izquierdo, Guzman: "Anti-tumoral action of cannabinoids: involvement
of sustained ceramide accumulation and extracellular signal-regulated
kinase activation" Nat Med 6,3 313-319 3.2000 THC lässt Hirntumore
(Gliome) bei Ratten schrumpfen.. |
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Di Marzo, Melck, De Petrocellis, Bisogno: "Cannabimimetic fatty
acid derivatives in cancer and inflammation" Prostaglandins Other
Lipid Mediat 61,1-2 43-61 4.2000 |
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De Petrocellis, Melck, Palmisano, Bisogno, Laezza, Bifulco, Di Marzo:
"The endogenous cannabinoid anandamide inhibits human breast cancer
cell proliferation" Chem Phys Lipids 108,1-2 191-209 11.2000 |
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Chan, Sills, Braun, Haseman, Bucher: "Toxicity and carcinogenicity
of delta 9-tetrahydrocannabinol in Fischer rats and B6C3F1 mice"
J Mol Med 78,11 613-625 2001 THC nicht karzinogen in Mäusen.. |
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Sánchez, de Ceballos, del Pulgar, Rueda, Corbacho, Velasco,
Galve-Roperh, Huffman, y Cajal, Guzman: "Inhibition of glioma growth
in vivo by selective activation of the CB(2) cannabinoid receptor"
Cancer Res 61,15 5784-5789 1.8.2001 |
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Recht, Salmonsen, Rosetti, Jang, Pipia, Kubiatowski, Karim, Ross,
Zurier, Litofsky, Burstein: "Antitumor effects of ajulemic acid
(CT3), a synthetic non-psychoactive cannabinoid" Biochem J 358,Pt
1 249-55 15.8.2001 |
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Parolaro, Massi, Rubino, Monti: "Endocannabinoids in the immune
system and cancer" J Pharmacol Exp Ther 299,3 951-959 12.2001 |
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White, Munson, Munson, Carchman: "Effects of delta9-tetrahydrocannabinol
in Lewis lung adenocarcinoma cells in tissue culture" Prostaglandins
Leukot Essent Fatty Acids 66,2-3 319-332 2.2002 |
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McKallip, Lombard, Fisher, Martin, Ryu, Grant, Nagarkatti, Nagarkatti:
"Targeting CB2 cannabinoid receptors as a novel therapy to treat
malignant lymphoblastic disease" Blood 100,2 627-634 15.7.2002 |
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US-Patent 6630507: Cannabioide als Antioxidanz und Nervenschutz. Hampson,
Axelrod, Grimaldi US-Gesundheitsministerium 21.4.1999 -> 7.10.2003
nützlich bei Schlaganfall, Traumata, Alzheimer, Parkinson, HIV,
Epilepsie.. |
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Casanova, Blázquez, Martínez-Palacio, Villanueva, Fernández-Aceñero,
Huffman, Jorcano, Guzman: "Inhibition of skin tumor growth and
angiogenesis in vivo by activation of cannabinoid receptors" J
Clin Invest 111,1 43-50 1.2003 |
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Blázquez, Casanova, Planas, Gómez Del Pulgar, Villanueva,
Fernández-Aceñero, Aragonés, Huffman, Jorcano,
Guzman: "Inhibition of tumor angiogenesis by cannabinoids"
FASEB J 17,3 529-531 3.2003 |
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Mimeault, Pommery, Wattez, Bailly, Hénichart: "Anti-proliferative
and apoptotic effects of anandamide in human prostatic cancer cell lines:
implication of epidermal growth factor receptor down-regulation and
ceramide production" Prostate 56,1 1-12 15.6.2003 |
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Guzman: "Cannabinoids: potential anticancer agents" Nat
Rev Cancer 3,10 745-755 10.2003 |
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Mimeault, Pommery, Wattez, Bailly, Hénichart: "Anti-proliferative
and apoptotic effects of anandamide in human prostatic cancer cell lines:
implication of epidermal growth factor receptor down-regulation and
ceramide production" Prostate 56,1 1-12 15.6.2003 |
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Massi, Vaccani, Ceruti, Colombo, Abbracchio, Parolaro: "Antitumor
effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma
cell lines" J Pharmacol Exp Ther 308,3 838-845 3.2004 Cannabis
gg. Gliome.. |
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Blázquez, González-Feria, Alvarez, Haro, Casanova, Guzman:
"Cannabinoids inhibit the vascular endothelial growth factor pathway
in gliomas" Cancer Res 64,16 5617-5623 15.8.2004 |
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Velasco, Galve-Roperh, Sánchez, Blázquez, Guzman: "Hypothesis:
cannabinoid therapy for the treatment of gliomas?" Neuropharmacology
47,3 315-323 9.2004 Cannabis gg. Gliome wie Glioblastoma multiforme
oder grade IV astrocytoma.. bösartige Hirntumore.. |
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Powles, Poele, Shamash, Chaplin, Propper, Joel, Oliver, Liu: "Cannabis-induced
cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors
and the MAPK pathway" Blood 105,3 1214-1221 1.2.2005 |
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Sarfaraz, Afaq, Adhami, Mukhtar: "Cannabinoid receptor as a novel
target for the treatment of prostate cancer" Cancer Res 65,5 1635-1641
1.3.2005 Cannabis als Zellwachstumshemmer, antientzündlich, Tumorrückbildung.. |
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McAllister, Chan, Taft, Luu, Abood, Moore, Aldape, Yount: "Cannabinoids
selectively inhibit proliferation and induce death of cultured human
glioblastoma multiforme cells" J Neurooncol 74,1 31-40 8.2005 |
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Kogan: "Cannabinoids and cancer" Mini Rev Med Chem 5,10
941-952 10.2005 |
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Patsos, Hicks, Dobson, Greenhough, Woodman, Lane, Williams, Paraskeva:
"The endogenous cannabinoid, anandamide, induces cell death in
colorectal carcinoma cells: a possible role for cyclooxygenase 2"
Gut 54,12 1741-1750 12.2005 |
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McKallip, Jia, Schlomer, Warren, Nagarkatti, Nagarkatti: "Cannabidiol-induced
apoptosis in human leukemia cells: a novel role of cannabidiol in the
regulation of p22 phox and Nox4 expression" Mol Pharmacol 70 897-908
2006 |
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Carracedo, Lorente, Egia, Blázquez, García, Giroux,
Malicet, Villuendas, Gironella, González-Feria, Piris, Iovanna,
Guzman, Velasco: "The stress-regulated protein p8 mediates cannabinoid-induced
apoptosis of tumor cells" Cancer Cell 9,4 301-312 4.2006 |
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Carracedo, Gironella, Lorente, Garcia, Guzman, Velasco, Iovanna: "Cannabinoids
induce apoptosis of pancreatic tumor cells via endoplasmic reticulum
stress-related genes" Cancer Res 66,13 6748-6755 1.7.2006 |
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Caffarel, Sarrió, Palacios, Guzman, Sánchez: "Delta9-tetrahydrocannabinol
inhibits cell cycle progression in human breast cancer cells through
Cdc2 regulation" Cancer Res 66,13 6615-6621 1.7.2006 |
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Guzman, Duarte, Blázquez, Ravina, Rosa, Galve-Roperh, Sánchez,
Velasco, González-Feria: "A pilot clinical study of Delta9-tetrahydrocannabinol
in patients with recurrent glioblastoma multiforme" Br J Cancer
95,2 197-203 17.7.2006 |
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Afaq, Sarfaraz, Syed, Khan, Malik, Bailey, Mukhtar: "Cannabinoid
receptors as a target for therapy of ovarian cancer" Proc Am Assoc
Cancer Res 47 2006 |
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Jia, Hegde, Singh, Sisco, Grant, Nagarkatti, Nagarkatti: "Delta9-tetrahydrocannabinol-induced
apoptosis in Jurkat leukemia T cells is regulated by translocation of
Bad to mitochondria" Mol Cancer Res 4,8 549-562 8.2006 |
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Gustafsson, Christensson, Sander, Flygare: "Cannabinoid receptor-mediated
apoptosis induced by R(+)-methanandamide and Win55,212-2 is associated
with ceramide accumulation and p38 activation in mantle cell lymphoma"
Mol Pharmacol 70,5 1612-1620 11.2006 |
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Ligresti, Moriello, Starowicz, Matias, Pisanti, De Petrocellis, Laezza,
Portella, Bifulco, Di Marzo: "Antitumor activity of plant cannabinoids
with emphasis on the effect of cannabidiol on human breast carcinoma"
J Pharmacol Exp Ther 318,3 1375-1387 9.2006 |
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Ligresti, Moriello, Starowicz, Matias, Pisanti, De Petrocellis, Laezza,
Portella, Bifulco, Di Marzo: "Antitumor activity of plant cannabinoids
with emphasis on the effect of cannabidiol on human breast carcinoma"
J Pharmacol Exp Ther 318,3 1375-1387 9.2006 THC erfolgreich gegen Krebs.. |
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Calatozzolo, Salmaggi, Pollo, Sciacca, Lorenzetti, Franzini, Boiardi,
Broggi, Marras: "Expression of cannabinoid receptors and neurotrophins
in human gliomas" Neurol Sci 28,6 304-310 12.2007 |
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McAllister, Christian, Horowitz, Garcia, Desprez: "Cannabidiol
as a novel inhibitor of Id-1 gene expression in aggressive breast cancer
cells" Mol Cancer Ther 6,11 2921-2927 11.2007 |
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Galanti, Fisher, Kventsel, Shoham, Gallily, Mechoulam, Lavie, Amariglio,
Rechavi, Toren: "Delta 9-tetrahydrocannabinol inhibits cell cycle
progression by downregulation of E2F1 in human glioblastoma multiforme
cells" Acta Oncol 47,6 1062-1070 2008 |
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Ramer, Hinz: "Inhibition of cancer cell invasion by cannabinoids
via increased expression of tissue inhibitor of matrix metalloproteinases-1"
J Natl Cancer Inst 100,1 59-69 2.1.2008 |
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Sarfaraz, Adhami, Syed, Afaq, Mukhtar: "Cannabinoids for cancer
treatment: progress and promise" Cancer Res 68,2 339-342 15.1.2008 |
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Michalski, Oti, Erkan, Sauliunaite, Bergmann, Pacher, Batkai, Müller,
Giese, Friess, Kleeff: "Cannabinoids in pancreatic cancer: correlation
with survival and pain" Int J Cancer 122,4 742-750 15.2.2008 gute
Bilder.. |
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Parolaro, Massi: "Cannabinoids as a potential new drug therapy
for the treatment of gliomas" Expert Rev Neurotherapeutics 8,1
37-49 1.2008 |
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Preet, Ganju, Groopman: "Delta9-Tetrahydrocannabinol inhibits
epithelial growth factor-induced lung cancer cell migration in vitro
as well as its growth and metastasis in vivo" Oncogene 27,3 339-346
10.1.2008 |
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Gustafsson, Wang, Severa, Eriksson, Kimby, Merup, Christensson, Flygare,
Sander: "Expression of cannabinoid receptors type 1 and type 2
in non-Hodgkin lymphoma: growth inhibition by receptor activation"
Int J Cancer 123,5 1025-1033 1.9.2008 |
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Liu, Scott, Shamash, Joel, Powles: "Enhancing the in vitro cytotoxic
activity of Delta9-tetrahydrocannabinol in leukemic cells through a
combinatorial approach" Leuk Lymphoma 49,9 1800-1809 9.2008 |
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Salazar, Carracedo, Salanueva, Hernández-Tiedra, Lorente, Egia,
Vázquez, Blázquez, Torres, García, Nowak, Fimia,
Piacentini, Cecconi, Pandolfi, González-Feria, Iovanna, Guzman,
Boya, Velasco: "Cannabinoid action induces autophagy-mediated cell
death through stimulation of ER stress in human glioma cells" J
Clin Invest 119,5 1359-1372 1.5.2009 THC erfolgreich gg.Krebs.. |
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Izzo, Camilleri: "Cannabinoids in intestinal inflammation and
cancer" Pharmacol Res 60,2 117-125 8.2009 |
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Marcu, Christian, Lau, Zielinski, Horowitz, Lee, Pakdel, Allison,
Limbad, Moore, Yount, Desprez, McAllister: "Cannabidiol enhances
the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma
cell proliferation and survival" Mol Cancer Ther 9,1 180-189 6.1.2010
THC als Universalmittel gg. Krebs.. zur Behandlung von Glioblastomen.. |
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Whyte, Al-Hammadi, Balhaj, Brown, Penefsky, Souid: "Cannabinoids
inhibit cellular respiration of human oral cancer cells" Pharmacology
85,6 328-335 2010 |
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Ramer, Merkord, Rohde, Hinz: "Cannabidiol inhibits cancer cell
invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1"
Biochem Pharmacol 79,7 955-966 1.4.2010 |
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Leelawat, Leelawat, Narong, Matangkasombut: "The dual effects
of delta(9)-tetrahydrocannabinol on cholangiocarcinoma cells: anti-invasion
activity at low concentration and apoptosis induction at high concentration"
Cancer Invest 28,4 357-363 5.2010 |
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Caffarel, Andradas, Mira, Pérez-Gómez, Cerutti, Moreno-Bueno,
Flores, García-Real, Palacios, Mañes, Guzman, Sánchez:
"Cannabinoids reduce ErbB2-driven breast cancer progression through
Akt inhibition" Mol Cancer 9 196 22.7.2010 |
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Torres, Lorente, Rodríguez-Fornés, Hernández-Tiedra,
Salazar, García-Taboada, Barcia, Guzman, Velasco: "A combined
preclinical therapy of cannabinoids and temozolomide against glioma"
Mol Cancer Ther 10,1 90-103 1.2011 Glioblastoma multiforme.. |
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Preet, Qamri, Nasser, Prasad, Shilo, Zou, Groopman, Ganju: "Cannabinoid
receptors, CB1 and CB2, as novel targets for inhibition of non-small
cell lung cancer growth and metastasis" Cancer Prev Res (Phila)
4,1 65-75 1.2011 |
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Foroughi, Hendson, Sargent, Steinbok: "Spontaneous regression
of septum pellucidum/forniceal pilocytic astrocytomas - possible role
of Cannabis inhalation" Childs Nerv Syst 27,4 671-679 4.2011 |
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Vara, Salazar, Olea-Herrero, Guzman, Velasco, Díaz-Laviada:
"Anti-tumoral action of cannabinoids on hepatocellular carcinoma:
role of AMPK-dependent activation of autophagy" Cell Death Differ
18,7 1099-1111 7.2011 |
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McAllister, Murase, Christian, Lau, Zielinski, Allison, Almanza, Pakdel,
Lee, Limbad, Liu, Debs, Moore, Desprez: "Pathways mediating the
effects of cannabidiol on the reduction of breast cancer cell proliferation,
invasion, and metastasis" Breast Cancer Res Treat 129,1 37-47 8.2011
Brustkrebs.. |
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"Boy, two, with brain cancer is 'cured' after secretly being
fed medical marijuana by his father" Daily mail online 4.5.2011
 |
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Ramos, Bianco: "The role of cannabinoids in prostate cancer:
Basic science perspective and potential clinical applications"
Indian J Urol 28,1 9-14 2012 |
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Ramer, Bublitz, Freimuth, Merkord, Rohde, Haustein, Borchert, Schmuhl,
Linnebacher, Hinz: "Cannabidiol inhibits lung cancer cell invasion
and metastasis via intercellular adhesion molecule-1" FASEB J 26,4
1535-1548 4.2012 |
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Aviello, Romano, Borrelli, Capasso, Gallo, Piscitelli, Di Marzo, Izzo:
"Chemopreventive effect of the non-psychotropic phytocannabinoid
cannabidiol on experimental colon cancer" J Mol Med (Berl) 90,8
925-934 8.2012 |
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Caffarel, Andradas, Pérez-Gómez, Guzman, Sánchez:
"Cannabinoids: a new hope for breast cancer therapy?" Cancer
Treat Rev 38,7 911-918 11.2012 |
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De Petrocellis, Ligresti, Moriello, Iappelli, Verde, Stott, Cristino,
Orlando, Di Marzo: "Non-THC cannabinoids inhibit prostate carcinoma
growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms"
Br J Pharmacol 168,1 79-102 1.2013 |
| |
Harrison: "Marijuana may lower bladder cancer risk" American
Urological Association (AUA) 2013 Annual Scientific Meeting 10.5.2013
Studie Thomas, Kaiser Permanente.. |
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Thomas, Wallner, Quinn, Slezak, Chien, Jacobsen: "Association
between cannabis use and risk of bladder cancer: Results from the California
Men's Health Study" Am Urological Assoc Ann Meeting, San Diego,
CA 4-8.5.2013 Abstract 1290.. 45% weniger Blasenkrebs.. |
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Scott, Shah, Dalgleish, Liu: "Enhancing the activity of cannabidiol
and other cannabinoids in vitro through modifications to drug combinations
and treatment schedules" Anticancer Res 33,10 4373-4380 10.2013 |
| |
Singh, Bali: "Cannabis extract treatment for terminal acute lymphoblastic
leukemia with a Philadelphia chromosome mutation" Case Rep Oncol
6,3 585-592 28.11.2013 Hanfölbehandlung.. |
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Armentano: "Emerging clinical applications for cannabis and cannabinoids.
A review of the recent scientific literature" 6. Fassung 31.1.2014 |
| |
Rocha, Júnior, Stefano, da Silveira: "Systematic review
of the literature on clinical and experimental trials on the antitumor
effects of cannabinoids in gliomas" J Neurooncol 116,1 11-24 1.2014 |
| |
McAllister, Soroceanu, Desprez: "The antitumor activity of plant-derived
non-psychoactive cannabinoids" J Neuroimmune Pharmacol 10,2 255-267
6.2015 Cannabis gg. Krebs.. |
| |
Maida, Daeninck: "A user's guide to cannabinoid therapies in
oncology" Curr Oncol 23,6 398-406 12.2016 Cannabis gg. Schmerzen,
Übelkeit, Erbrechen, Krebs, als Appetitanreger.. |
| |
Thiele: "Cannabis. Verkannte Heilpflanze. Die Wunderpflanze?"
Revue 42 15-20 19.10.2016 Hanf gg. Multiple Sklerose MS, Krebs, Hirntumor,
ADHS.. |
| |
Volmar, Cheng, Alenezi, Richter, Haug, Hassan, Goldberg, Li, Hou,
Herold-Mende, Maire, Lamszus, Flüh, Held-Feindt, Gargiulo, Topping,
Schilling, Saur, Schneider, Synowitz, Schick, Kälin, Glass: "Cannabidiol
converts NFkB into a tumor suppressor in glioblastoma with defined antioxidative
properties" Neuro Oncol noab095 17.4.2021 Krebs.. |
